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A new development in multiphoton microscopy, members of the Peter Saggau laboratory at Baylor College of Medicine in Houston have developed the first multiphoton microscope that can capture 3-D images of a calcium wave in a single neuron.

In experiments detailed in the June 2008 issue of Nature Neuroscience, the researchers performed structural and functional imaging of neurons in rat brain slices, rapidly scanning many user-selected sites on dendrites.

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